Page 13 Point-of-care electrochemical sensors for cancer diagnosis and cancer management Prof Pedro Estrela Centre for Bioengineering & Biomedical Technologies (CBio) and Department of Electronic and Electrical Engineering, University of Bath, United Kingdom p.estrela@bath.ac.uk There is a great need for low-cost biosensor chips capable of parallel detection of cancer biomarkers to be used in portable instrumentation. In order to realise the promise of liquid biopsies, such devices need to be robust and provide a combination of high selectivity and sensitivity.As we move towards a telehealth model where patients under treatment or on surveillance test themselves or at community-level facilities, biosensors can further provide the speed, low cost and portability required for point-of-care testing. Electrochemical methods are inherently low-cost, miniaturisable and easily integrated into multiplexed systems for the parallel screening of panels of biomarkers. Of particular interest are biologically sensitive field-effect transistors (BioFETs) and impedance-based sensors (both Faradaic and non-Faradaic impedance). Improved selectivity and robustness can be provided by using synthetic molecules such as DNA aptamers, peptide aptamers (Affimers) and molecularly imprinted polymers as alternatives to antibodies. We have developed a range of biosensors for the multiplexed detection of protein biomarkers, microRNAs and cancer cells. Such biosensors can be integrated with microfluidics and electronic addressing for on-chip sample preparation (e.g. separation, pre-concentration), sensing and data transmission in fully functional Lab-on-Chip biodevices for point-of-care applications. Pedro Estrela is Professor of Biosensors and Bioelectronics at the Department of Electronic & Electrical Engineering and Director of the Centre for Bioengineering & Biomedical Technologies (CBio) at the University of Bath. He has a background in Physics (degree and Masters from the University of Lisbon, PhD from the University of Amsterdam) and started working in the field of biosensors in 2000 (University of Cambridge until 2008 and University of Bath since 2008). He is a member of the Steering Committee of the Centre for Therapeutic Innovation (CTI) and committee member of the Cancer Research at Bath (CR@B) network. Prof. Estrela’s research focuses on the development of label-free electrical, electrochemical and plasmonic biosensors for a wide range of applications such as medical diagnostics and environmental monitoring. He has over 165 peer-reviewed publications (Scopus h-index 39), many of them in high impact journals in the fields of biosensors and analytical chemistry. He is an Associate Editor for the journals Biosensors & Bioelectronics, Scientific Reports, Sensors, Frontiers in Sensors and Advanced Devices & Instrumentation and Specialty Chief Editor in Frontiers in Lab on a Chip Technologies.
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