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April 2017

Tracking Unstable Chromosomes Helps Predict Lung Cancer’s


Scientists at the Francis Crick Institute and UCL in London have found that unstable

chromosomes within lung tumours increase the risk of cancer returning after surgery,

and have used this new

knowledge to deter-

mine the risk of relapse

up to a year before the

cancer returns. These

are the first find-

ings from the Cancer

Research UK-funded

TRACERx lung cancer

study, published in the

New England Journal of

Medicine and Nature.

In the trial, funded by Cancer Research UK, samples were taken from the lung tumour

when it was removed during surgery. A team at the Francis Crick Institute, in London,

then analysed the tumour’s defective DNA to build up a genetic fingerprint of each

patient’s cancer. Then blood tests were taken every three months after the surgery

to see if tiny traces of cancer DNA re-emerged. The results, outlined in the journal

Nature, showed cancer recurrence could be detected up to a year before any other

method available to medicine.

Francis Crick Institute

26 April

Grail Launches Clinical Trial for Early Detection of Breast


Grail said that it has begun a clinical trial, STRIVE, for its next-generation sequencing-

based blood test for early-stage cancer detection.The firm will collaborate with the

Mayo Clinic and Sutter Health to enroll up to 120,000 women at the time when they

receive a mammogram.The goal will be to train and validate the test.

genomeweb 2

0 April

Cancer Diagnostic News